Mice choriocapillaris has variation in morphology. In the upper image, choriocapillaris is a sheet of the endothelial cells (within the square line), while in the other areaschoriocapillaris shows mono-layered vascular network. In the middle image, the upper site is a sheet of the endothelial cells. The lower image is the high magnification view of the area surrounded with rectangle in the middle image. pericytes (arrows) fit the endothelial cells which have nuclear swellings. These findings show that remodeling of the choriocapillaris occurs in adult eye and it is by intussusception. Pericytes may remove from choriocapillaris in parallel with remodeling from sheets of endothelial cells to capillary network by VEGF from pigmented epithelial cells.
These are the images of Bruch's membrane (No 1, B) and choriocapillaris (C). No. 1 is a view from RPE (retinal pigmented epithelium). No. 2 is a Bruch membrane composed of collagen fibers. No. 3 is a higher magnification view of the choriocapillaris in No. 1. No. 4 is a high magnification view of choriocapillaris. Endothelial cells of choriocapillaris have fenestrations.
Mice choriocapillaris has variation in morphology. In the upper image, choriocapillaris is a sheet of the endothelial cells (within the square line), while in the other areaschoriocapillaris shows mono-layered vascular network. In the middle image, the upper site is a sheet of the endothelial cells. The lower image is the high magnification view of the area surrounded with rectangle in the middle image. pericytes (arrows) fit the endothelial cells which have nuclear swellings. These findings show that remodeling of the choriocapillaris occurs in adult eye and it is by intussusception. Pericytes may remove from choriocapillaris in parallel with remodeling from sheets of endothelial cells to capillary network by VEGF from pigmented epithelial cells.
